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InChiKey: VENOXIKBBUVHRY-UHFFFAOYSA-N
and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells
LY2784544 shows anti-proliferative activity in JAK2 V617F-driven cells with an IC50 of 68 nM
a lysophosphatidic acid 1 receptor antagonist
Stefanutti C
RKI-1447 - CAS# 1342278-01-6 Catalog No.:M60415-2S InChiKey: VENOXIKBBUVHRY-UHFFFAOYSA-NRKI 1447, CAS No. 1342278 01 6, is a potent inhibitor of the Rho associated ROCK kinases with anti invasive and antitumor activities in breast cancer. RKI 1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI 1447 suppressed phosphorylation of the ROCK substrates MLC 2 and MYPT 1 in human cancer cells. Product information CAS Number: 1342278 01 6 Molecular Weight: 326. 37
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