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PubMed PMID: 24829950
1-dimethylethyl)pyrazolo[1
TG101209 is an orally bioavailable
also known as Pavulon and NA-97
ζ-Stat (5 µM
LEE011 succinate spimycin PubMed PMID: 24829950Ribociclib Free Base, also known as LEE011, is an orally available cyclin dependent kinase (CDK) inhibitor targeting cyclin D1 CDK4 and cyclin D3 CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4 6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK mediated G1 S phase transition, thereby arresting the cell cycle in the G1