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The Hedgehog Signaling Pathway as a Target for Anticancer Drug Discovery
1028486-01-2
resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis
1222800-79-4
InChi: InChI=1S/C28H26ClF2N3OS/c1-32-20-5-7-21(8-6-20)34(16-17-3-2-4-19(15-17)18-11-13-33-14-12-18)28(35)27-25(29)24-22(30)9-10-23(31)26(24)36-27/h2-4
EPZ-6438 - EZH2 Methyltransferase Inhibitor. CAS# 1403254-99-8 nsferase The Hedgehog Signaling Pathway asEPZ 6438 (E7438), CAS No. 1403254 99 8, is a potent and selective small molecule inhibitor of histone methyltransferase EZH2. It inhibited the activity of human PRC2 containing wild type EZH2 with an inhibition constant (Ki) value of 2. 5 0. 5 nM, and similar potency was observed for EZH2 proteins bearing all known lymphoma change of function mutations. EPZ 6438 inhibits EZH2 in a manner competitive with the substrate S adenosylmethionine (SAM). EPZ
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