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Vorinostat olnaftate [Epub ahead of print] PubMed

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[Epub ahead of print] PubMed PMID: 29516568

CAS Number: 321695-57-2

Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis

Grossberg GT

Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18

Vorinostat olnaftate [Epub ahead of print] PubMedVorinostat, also known as suberanilohydroxamic acid, MK 0683 and SAHA, is a potent and selective inhibitor of histone deacetylases (HDACs). Vorinostat has been shown to bind to the active site of histone deacetylases and act as a chelator for Zinc ions also found in the active site of histone deacetylases. Vorinostat's inhibition of histone deacetylases results in the accumulation of acetylated histones and acetylated proteins, including transcription

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