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InChiKey: XEAOPVUAMONVLA-QGZVFWFLSA-N
GTS-21 hydrochloride
The MI/AAR ratio is significantly reduced in the 50 mg/kg group compared with the 5 mg/kg and vehicle groups
InChi: InChI=1S/C13H16N4O
Smiles: CN1C=NC2=C(F)C(NC3=CC=C(Br)C=C3Cl)=C(C=C12)C(=O)NOCCO
SGI-1776 oliquiritigenin InChiKey: XEAOPVUAMONVLA-QGZVFWFLSA-NSGI 1776 is a small molecule pan Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI 1776 binds to and inhibits the activities of Pim 1, 2 and 3, serine threonine kinases, which may result in the interruption of the G1 S phase cell cycle transition, the expression of pro apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be
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