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Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs)
pii: S0889-1591(15)00428-6
Chemical Name: 1-butyl-N-(2
Formula: C44H32N4O4
Solubility: DMSO: 125 mg/mL (477
A-867744 - CAS# 1000279-69-5 terin) Pyrazolinone-piperidine dipeptide growth hormone secretagoguesA 867744 is a type II PAM with good potency and selectivity. A 867744 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs. In a rodent model of sensory gating, A 867744 normalized gating deficits. A 867744 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs. A 867744 potentiated acetylcholine (ACh) evoked currents, with an EC(50) value of approximately 1
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