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CFTR(Inh)172
with novel features that make it a promising compound for the therapy and prophylaxis of all forms of theileriosis
Also inhibits other common kinases including EGFR (IC50 = 4 nM)
Neuronal cultures treated with other toxic stimuli such as staurosporine
InChi: InChI=1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3
SR1078 - CAS# 1246525-60-9 acapone CFTR(Inh)172SR 1078 is a selective agonist of ROR and ROR that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 M without effect at the related liver X receptors and farnesoid X receptors. SR1078 modulates the conformation of ROR in a biochemical assay and activates ROR and ROR driven transcription. SR1078 stimulates expression of endogenous ROR target genes in HepG2 cells that express both ROR and ROR. SR1078
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