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Chemical Name: 4-amino-7-[(2R
InChiKey: PNTVCCRNJOGKGA-QFIPXVFZSA-N
Delgocitinib also inhibits IL-2-induced proliferation of T cells in a concentration-dependent manner (IC50=8
Galeterone (TOK-001) affords strong CYP17 lyase inhibition
Formula: C77H96ClF3N10O10S4
Tankyrase Inhibitors (TNKS) 22 halin Chemical Name: 4-amino-7-[(2RTankyrase Inhibitors (TNKS) 22 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis
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