UF010 - HDAC Inhibitor. CAS# 537672-41-6 Catalog No.:M60278-2S InChi: InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5

InChi: InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5

Su-11274 exhibits a selective inhibition pattern toward different receptor mutated variants

PubMed PMID: 10762053

InChi: InChI=1S/C18H19F3N2O4S2

Ciraparantag

UF010 - HDAC Inhibitor. CAS# 537672-41-6 Catalog No.:M60278-2S InChi: InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5UF 010, CAS No. 537672 41 6, is a Class I HDAC inhibitor (IC50 values are 0. 06, 0. 1, 0. 5 and 1. 5 M for HDACs 3, 2, 1 and 8, respectively). UF010 inhibits cancer cell proliferation via class I HDAC inhibition. This causes global changes in protein acetylation and gene expression, resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways. The isotype selectivity coupled with interesting biological