Age counters can force your opponent to sacrifice their precious indestructible baby if they cant keep up with the cumulative upkeep cost, so making something like Mystic Remora indestructible won't achieve much
Not only does it synergize with a variety of spells that do 1 damage like Spikefield Hazard and Gut Shot, but it also works well with spell-casting payoffs like Thermo-Alchemist, cards like Witty Roastmaster that deal 1 damage with the alliance trigger, as well as all those pingers like Prodigal Sorcerer
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Things quickly add up to about 40 products per year
The way the card is worded, turning off lifegain lasts for the rest of the game, regardless of whether Screaming Nemesis leaves the battlefield, along the same lines as Stigma Lasher
In my experience, you dont need to go overkill with your ramp options, though
