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1S xenograft by IP injection at 50 mg/kg (5 days a week)
It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3-kinases in the signal transduction pathways involved in cell migration
It can inhibit the enzymatic activity of IDH1 R132H in vitro with an IC50 < 0
an investigational
specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 ~1
BI-9564 - BRD9 Bromodomain Inhibitor. CAS# 1883429-22-8 size:2 mg solid 1S xenograft by IP injectionBI 9564, CAS No. 1883429 22 8, is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14. 1 and 239 nM; IC50s = 75 nM and 3. 4 M, respectively). BI 9564 is useful in further exploring BRD9 bromodomain biology in both in vitro and in vivo settings. Selective inhibitors of bromodomain containing protein 9 (BRD9) may have therapeutic potential in the treatment of human malignancies and inflammatory diseases. Product information CAS