RGB-286638 free base anaxatriol 24 and 23 nM for

24 and 23 nM for PKCα

is an AMPA receptor modulator potentially for the treatment of cognitive deficits

Purvalanol A is a 2

PubMed Central PMCID: PMC3562069

with virtually complete inhibition at 10 μM

RGB-286638 free base anaxatriol 24 and 23 nM forRGB 286638 is a multitargeted cyclin dependent kinase inhibitor. RGB 286638 triggers P53 dependent and independent anti multiple myeloma activity through inhibition of transcriptional CDKs. GB 286638 treatment resulted in MM cytotoxicity in vitro associated with inhibition of MM tumor growth and prolonged survival in vivo. RGB 286638 displayed caspase dependent apoptosis in both wt p53 and mutant p53 cells that was closely associated with the