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is PLX647 is a potent inhibitors of both FMS and KIT that show strong selectivity compared with other kinases
is a pan-Janus-activated kinase inhibitor
SKPin C1 was used at 10 µM final concentration in various in vitro assays
Yoshimura C
InChi: InChI=1S/C26H27FN2O2/c1-17-12-18(2)14-21(13-17)24-4-3-11-29(24)16-19-5-8-22(9-6-19)31-25-10-7-20(26(28)30)15-23(25)27/h5-10
SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 size:10 mg solid is PLX647 is a potentSW033291, CAS No. 459147 39 8, is a highly potent and selective inhibitor of 15 PGDH enzyme with IC50 1. 5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15 PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3. 5 fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue