EGFR-IN-1 hydrochloride Catalog No.:M27662-C Smiles: C[C@@H]1NN[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N[C@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)C(=O)[C@H](CC1C=CC(O)=CC=1)NC2=O

Smiles: C[C@@H]1NN[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N[C@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)C(=O)[C@H](CC1C=CC(O)=CC=1)NC2=O

20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals

Formula: C13H16N2O4S

InChi: InChI=1S/C13H22N6

Smiles: COC1C=C(C=C(C=1)OC)C=CC1C=CC(O)=CC=1

EGFR-IN-1 hydrochloride Catalog No.:M27662-C Smiles: C[C@@H]1NN[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N[C@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)C(=O)[C@H](CC1C=CC(O)=CC=1)NC2=OEGFR IN 1 hydrochloride is an orally active and irreversible L858R T790M mutant selective EGFR inhibitor. EGFR IN 1 hydrochloride potently inhibits Gefitinib resistant EGFR L858R, T790M with 100 fold selectivity over wild type EGFR. EGFR IN 1 hydrochloride displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity. Product information CAS Number: 2227455 78 7 Molecular Weight: 551. 04