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Effects of a newly synthesized K+ channel opener
InChi: InChI=1S/C15H16O6S/c1-7-4-12(17)21-11-5-8(2-3-9(7)11)20-15-14(19)13(18)10(16)6-22-15/h2-5
3)20-12(16)15-5-7-18-9-11-19-10-8-17-6-4-14/h4-11
InChiKey: ZUINPPQIQARTKX-UHFFFAOYSA-N
+1/p-1/b26-20-
Sulindac sulfone Size:Contact [email protected] for quotation Effects of a newly synthesizedSulindac sulfone is a metabolite of the nonsteroidal anti inflammatory drug (NSAID) sulindac. In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA 7 cells with an IC50 of 360 mmol L. Sulindac sulfone at 100 mmol L reduced 6 ketoPGF by 29. 2%. Sulindac sulfone reduced the colony number of HCA 7 and HCT 116 with an EC50 of 50 mmol l. Sulindac sulfone significantly decreased the expression of total cellular catenin (50% of control),