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SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM
InChiKey: HWEOXFSBSQIWSY-MRXNPFEDSA-N
DJ001 treatment also significantly increases the numbers of colony forming cells (CFCs) in 3 day culture of BM KSL cells
InChi: InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7
polarization of endomembranes
SAH-SOS1A TFA Catalog No.:M16665-C SIAIS178 is a potent andSAH SOS1A TFA is a peptide based SOS1 KRAS protein interaction inhibitor. SAH SOS1A TFA binds to wild type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106 175 nM) and directly and independently blocks nucleotide association. SAH SOS1A TFA impairs KRAS driven cancer cell viability and exerts its effects by on mechanism blockade of the ERK MAPK phosphosignaling cascade downstream of KRAS. Product information
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