Actually a lot of decks may ignore Wrenn and Six since theyre either faster than its minus 7 ability or Wrenn and Six just doesnt have the impact to deal with any creature theyre presenting

Drannith Magistrate Enlightened Tutor Serras Sanctum Smothering Tithe Trouble in Pairs Cyclonic Rift Expropriate Force of Will Fierce Guardianship Rhystic Study Thassas Oracle Urza, Lord High Artificer Mystical Tutor Jin-Gitaxias, Core Augur Bolass Citadel Demonic Tutor Imperial Seal Opposition Agent Tergrid, God of Fright Vampiric Tutor Ad Nauseam Jeskas Will Underworld Breach Survival of the Fittest Vorinclex, Voice of Hunger Gaeas Cradle Kinnan, Bonder Prodigy Yuriko, The Tigers Shadow Winota, Joiner of Forces Grand Arbiter Augustine IV Ancient Tomb Chrome Mox The One Ring The Tabernacle at Pendrell Vale Trinisphere Grim Monolith Lions Eye Diamond Mox Diamond Mana Vault Glacial Chasm An important thing to keep in mind for the future is that the Game Changers list also serves as a half step to banning or unbanning a card
That same flexibility could be turned against it
Illustrated by Steve Prescott Standard Legal Alchemy Legal Pioneer Legal Historic Legal Modern Legal Brawl Legal Legacy Legal Comp
This is not only totally wild, but it also presents logistical challenges
Except for rule inserts and tokens, which are made of a different card stock and dont use the opaque glue that regular MTG cards do