GDC-0032 Size:Solid 2 mg CAS Number: 157716-52-4

CAS Number: 157716-52-4

Chemical Name: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol hydrochloride

a key step in cholesterol synthesis

Smiles: CC(C)(C)C1C=CC(=CC=1)C(=O)NC(=S)NC1C=CC(N)=CC=1

Smiles: CC1NC(/C=C2/C3=CC(=CC=C3NC/2=O)S(=O)(=O)CC2C(Cl)=CC=CC=2Cl)=C(C)C=1C(=O)N1CCC[C@@H]1CN1CCCC1

GDC-0032 Size:Solid 2 mg CAS Number: 157716-52-4Taselisib, also known as GDC0032 or RG7606, is a selective, potent, orally bioavailable inhibitor of PI3Ka with a Ki = 0. 2nM, and with reduced inhibitory activity against PI3K. This selectivity profile, and excellent pharmacokinetic and pharmaceutical properties, allowed for greater efficacy in vivo at the maximum tolerated dose relative to a pan Class I PI3K inhibitor in PIK3CA mutant xenografts. Notably, GDC 0032 preferentially inhibited PIK3CA