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000-fold selective versus the >200-fold selectivity of other protein kinases tested in biochemical assays
Epub 2010 Aug 1
26)17-9-8-12(11-14(17)20)22-18(24)16-7-3-4-10-21-16/h1-11
anchorage-independent growth
It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells
BI-3812 M2 proteins-interaction-inhibitor dihydrochloride 000-fold selective versus the >200-foldBI 3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of 3 nM; BI 3812 has antitumor activity. Product information CAS Number: 2166387 64 8 Molecular Weight: 558. 03 Formula: C26H32ClN7O5 Chemical Name: 1 [5 chloro 4 ({8 methoxy 1 methyl 3 [(methylcarbamoyl)methoxy] 2 oxo 1, 2 dihydroquinolin 6 yl}amino)pyrimidin 2 yl] N, N dimethylpiperidine 4 carboxamide Smiles:
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