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InChiKey: FBFBRAFXKGRRHI-UHFFFAOYSA-N
suggesting its therapeutic potential
Solubility: DMSO 100 mg/mL (143
Chihoko Yoshimura
Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects
CP-466722 Size:Solid 10 mg InChiKey: FBFBRAFXKGRRHI-UHFFFAOYSA-NCP 466722 is an ATM inhibitor. CP466722 inhibited cellular ATM dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP466722. Interestingly, clonogenic survival assays showed that transient inhibition of ATM is sufficient to sensitize cells to IR and suggests that therapeutic radiosensitization